Abstract: ObjectiveTo explore the application of individual operation and perioperation period processing in the treatment of gastric cancer complicated with portal hypertension( PHT) . Methods: The clinical data of 18 patients with gastric cancer complicated with PHT treated with individual treatment were retrospectively analysed.Seventeen cases were treated with D2 radical operation，1 case was treated with palliative resection，6 cases were treated with splenectomy combined with pericardial devascularization，and 8 cases were treated with splenectomy.Results: Ascites in 16 cases， intra-abdominal hemorrhage in 2 cases， intra-abdominal abscess in 1 case，incision infection in 1 cases and wound dehiscence in 1 case were found.All patients recovered after active treatment. Conclusions: The operation， treatment and postoperative complications in patients with gastric cancer with PHT are complex，difficult and more.The individual operation and perioperation period processing in the treatment of gastric cancer complicated with PHT are feasible.