Abstract: ObjectiveTo evaluate the clinical effects of laser combined with iodized lecithin tablets in the treatment of central serous chorioretinopathy( CSC) . Methods: Fifty-five patients( 57 eyes) with CSC( fundus leakage in more than 500 m from the center of central fovea of macula) were randomly divided into treatment group and control group.The control group( 26 cases，31 eyes) were treated with 532 laser photocoagulation.The treatment group( 29 cases， 31 eyes) were treated with 532 laser photocoagulation combined with iodized lecithin tablets by oral.The vision， fundus and fluorescence fundus angiography( FFA) of two groups were observed 2，4 weeks and 3 months after treatment.Results: The vision of two groups were significantly improved after treatment( P 0.01) ， the vision of treatment group were significantly higher than those in control group 2 and 4 weeks after treatment( P 0.01) ， the difference of vision in two group was not statistical significance 3 months after treatment( P 0.05) .The difference of cure rate between two groups had no statistical significance( P 0.05) .The disappearance rate of self-conscious symptom in treatment group was higher than that in control group in 3 months after treatment ( P 0.01 ) .The difference of reoccurrence rate between two groups had no statistical significance( P 0.05) . Conclusions: The 532 laser combined with iodized lecithin tablets for treating CSC is safe and effective，which can shorten the course of disease and strengthen the repairing effects of non-treatment area in retina.