Abstract: ObjectiveTo analyze the risk factor which progressing to cerebral infarction( CI) after transient ischemic attack( TIA) in a short term. Methods: Twenty-four cases of the total 92 TIA patients who progressing to CI were included into experimental group and the rest 68 patients were included into control group.Used single factor analysis， the influence factors of CI which progressed from TIA were analyzed by multi-factor logistic analysis.The progression to CI of the different ABCD2 scores in 30 days were observed.Results:There were significant differences between the two groups in hypertension，diabetes， coronary artery disease， symptoms duration time and intracranial artery stenosis ( P 0.05 to P 0.01) .The results of multi-factor analysis showed that intracranial artery stenosis，symptoms duration time which was longer than 60 minutes，diabetes，hypertension and coronary artery disease were all the risk factors of the progression( P 0.05 to P 0.01) .The scores of ABCD2 was highe， the possibility of progression to CI was increased( P 0.05) . Conclusions: ABCD2 scale not only includes the risk factors of diabetes and hypertension，also contains the assessment of symptom.ABCD2 scale is convenient to be used in clinic and the accuracy will be enhanced if combining with imaging examine.