Abstract: Objective: To investigate the related factors and preventive measures for nosocomial infection(NI) in the Department of Geriatrics. Methods: The clinical data of 673 cases of elderly inpatients were analyzed. The single factor analysis and logistic regression analysis about the variable quantity of the influence factors which induced NI were performed. Results: Among the 673 inpatients,52 patients were gotten NI. The most common NI usually was occurred in lung,upper respiratory tract, gastrointestinal or urinary tract. In the related examination for variable quantity of single factor, the time of staying in hospital, age,diabetes, cerebral vascular disease and invasive manipulation were the independent dangerous factors of NI. The staying time in hospital was the most improtant factor. Conclusions: The time of staying in hospital,age,diabetes,cerebral vascular disease and invasive manipulation were the independent dangerous factors that contribute to NI of inpatients. Prevention and cure of these factors should be emphasized to decrease the incidence of NI in elderly inpatients.