Abstract: Objective: To investigate the endoscopic and pathologic characteristics of 52 cases with the serrated adenoma of large intestine. Methods: The endoscopic and pathologic characteristics of 52 cases with the serrated adenoma of large intestine were retrospectively analysed. Results: Among 52 cases with serrated adenoma, there were 19 cases in rectum, 13 cases in sigmoid colon, 2 cases in the junction of rectum and sigmoid colon, 6 cases in descending colon, 8 cases in transverse colon, 3 cases in ascending colon and 1 case in cecum. One case with multiple adenoma and 51 cases with single adenoma were found, which diameters were 1 to 25 mm. Fifty-five cases with serrated adenoma included 32 cases with wide base polyps, 15 cases with sub-pedicle polyps and 5 cases with pedicle polyps. The pathologic examination showed 17 cases with pure serrated adenoma, 33 cases with serrated adenoma complicated with low grade intraepithelial neoplasia, 1 case with serrated adenoma complicated with high grade intraepithelial neoplasia and 1 case with local malignant of serrated adenoma. Conclusions: The clinical symptoms of serrated adenoma are non-specificity, the single and wide base polyps complicated with intraepithelial neoplasia are most, located in rectum.