Abstract: Objective: To observe the clinical effect of budesonide combined with salbutamol atomization inhalation on acute exacerbation phase of chronic obstructive pulmonary disease(AECOPD) . Methods: One hundred patients with AECOPD were randomly divided into two groups:50 patients in control group were injected with dexamethasone(10 mg) intravenously once a day; 50 patients in observed group were treated with budesonide(1 mg) combined with salbutamol(0. 5 ml) atomization inhalation twice a day. The changes of clinical symptom scores, electrolytes levels, blood glucose levels, lung function, blood gas analysis including forced expiratoy volume in the first second, PaO2 and PaCO2 on the first day of 7th day of treatment and the last day before discharge were recorded, meanwhile the side effects were observed. Results: FEV1, PaO2 and PaCO2 in these two groups were improved, and there was significant difference after treatment(P ＜ 0. 05-P ＜ 0. 01) ; the side effect in observed group was significantly less than that in control group. Conclusions: The treatment of budesonide combined with salbutamol atomization inhalation can improve lung function and clinical symptom of patients with AECOPD, which is superior to the effect of intravenous glucocorticoid, and the adverse effect has decreased.