Abstract: Objective: To improve the radical resection rate of hilar cholangiocarcinoma and long-term effect.Methods: Twenty-seven cases were radically resected.Left liver and caudate lobe of 3 cases and right liver and caudate lobe of 3 cases were resected.Thirteen cases were treated with palliative operation, and 9 cases and 4 cases were drained through gallbladder-intestine and extrahepatic duct,repectively.Results: The radical resection rate was 67.5%.The 1,2 and 3 year survival rates of 40 patients treated with radical resection were 76.0%,36.0% and 16.0%, respectively,which median survival time was 20 months.The median survival time of patients treated with palliative operation combined with inside and outside drainage were 12 and 8 months, respectively.Conclusions: The selection of suitable cases can improve the radical resection rate of hilar cholangiocarcinoma.The radical resection is an effective means to improve the long-term survival rate of hilar cholangiocarcinoma.