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    董毅, 朱太岗, 张飞虎, 汤继春, 夏瑞祥, 曾庆曙, 葛健. 骨髓自然杀伤细胞水平对急性髓细胞性白血病患者预后的影响[J]. 蚌埠医科大学学报, 2014, 38(2): 204-206.
    引用本文: 董毅, 朱太岗, 张飞虎, 汤继春, 夏瑞祥, 曾庆曙, 葛健. 骨髓自然杀伤细胞水平对急性髓细胞性白血病患者预后的影响[J]. 蚌埠医科大学学报, 2014, 38(2): 204-206.
    shu
    Dong Yi, Zhu Taigang, Zhang Feihu, Tang Jichun, Xia Ruixiang, Zeng Qingshu, Ge Jian. The effect of natural killer cells level in bone marrow on the prognosis of patients with acute myeloid leukemia[J]. Journal of Bengbu Medical University, 2014, 38(2): 204-206.
    Citation: Dong Yi, Zhu Taigang, Zhang Feihu, Tang Jichun, Xia Ruixiang, Zeng Qingshu, Ge Jian. The effect of natural killer cells level in bone marrow on the prognosis of patients with acute myeloid leukemia[J]. Journal of Bengbu Medical University, 2014, 38(2): 204-206.
    shu

    骨髓自然杀伤细胞水平对急性髓细胞性白血病患者预后的影响

    The effect of natural killer cells level in bone marrow on the prognosis of patients with acute myeloid leukemia

      摘要
    • 摘要: 目的：探讨骨髓自然杀伤(natural killer,NK)细胞水平对急性髓细胞性白血病(acute myeloid leukemia,AML)患者预后的影响。方法：研究分成AML初治组40例,缓解组20例,正常对照组20例。均抽取骨髓液2 ml,采用直接免疫荧光标记法对骨髓有核细胞进行单克隆抗体(CD16+/CD56+)标记,应用流式细胞仪进行NK细胞数量的检测。结果:初治组患者骨髓NK细胞表达水平较缓解组显著降低(P0.01)。缓解组患者骨髓NK细胞表达水平仍低于对照组(P0.05)。不同骨髓NK细胞表达水平间原始细胞数量和AML患者疗效差异均有统计学意义(P0.01和P0.05)。结论：骨髓NK细胞表达水平可以作为AML的预后指标,亦有助于指导治疗。

       

      Abstract: Objective: To explore the effects of natural killer (NK) cells in bone marrow on the prognosis of patients with acute myeloid leukemia(AML). Methods: Sixty patients with AML were divided into original treating group(40 cases) and remission group (20 cases), 20 health people were served as control group． The CD16 + /CD56 + of monoclonal antibodies in bone marrow nucleatedcells of three groups were detected by direct immunofluorescence labeling method， the levels of NK cells were determined with flowcytometry． Results: The levels of NK in original treating group were significantly lower than those in remission group(P ＜ 0． 01), the levels of NK in remission group were significantly lower than those in normal group(P ＜ 0． 05). The original cell number in different NK cell levels and the differences of curative effect in AML patients were statistically significant(P ＜ 0． 01 and P ＜ 0． 05). Conclusions:The level of NK cells in bone marrow is a prognostic index of AML and can help to guide treatment．

       

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