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    何启胜. 依帕司他联合前列地尔治疗糖尿病周围神经病变的临床观察[J]. 蚌埠医科大学学报, 2014, 38(3): 318-319,323.
    引用本文: 何启胜. 依帕司他联合前列地尔治疗糖尿病周围神经病变的临床观察[J]. 蚌埠医科大学学报, 2014, 38(3): 318-319,323.
    shu
    HE Qisheng. Epalrestat combined with alprostadil for treatment of diabetic peripheral neuropathy[J]. Journal of Bengbu Medical University, 2014, 38(3): 318-319,323.
    Citation: HE Qisheng. Epalrestat combined with alprostadil for treatment of diabetic peripheral neuropathy[J]. Journal of Bengbu Medical University, 2014, 38(3): 318-319,323.
    shu

    依帕司他联合前列地尔治疗糖尿病周围神经病变的临床观察

    Epalrestat combined with alprostadil for treatment of diabetic peripheral neuropathy

      摘要
    • 摘要: 目的:观察依帕司他联合前列地尔治疗糖尿病周围神经病变(DPN)的疗效。方法:将76例DPN患者随机分为2组:治疗组39例,静脉滴注前列地尔10g/d,口服依帕司他3次/天,每次50 mg;对照组37例,口服维生素B1,每次10 mg,3次/天代替依帕司他,其余同治疗组。2组均治疗4周。记录治疗前后主要症状、体征及肌电图的改变。结果:治疗组临床疗效和神经传导速度改善均优于对照组(P0.01)。结论:依帕司他联合前列地尔治疗DPN安全有效,且临床疗效优于维生素B1联合前列地尔。

       

      Abstract: Objective:To observe the clinical effect of epalrestat combined with alprostadil on diabetic peripheral neuropathy(DPN)． Methods:Seventy-six patients with DPN were randomly divided into two groups． The treatment group(39 cases) were administered intravenous infusion of alprostadil(10 g/d) and oral epalrestat(50 mg/time，3 times/d)，while the control group(37 cases) were treated with intravenous infusion of alprostadil(10 g/d) and oral vitamin B1(10 mg/time，3 times/d)． The patients' symptoms，signs and changes of electromyography were compared before and after treatment． Results:The treatment group were superior to the control group in clinical efficacy and improvement of the nerve conduction velocity(P 0． 01)． Conclusions:Epalrestat combined with alprostadil is safe and effective in the treatment of diabetic peripheral neuropathy，and the curative effect is better than the therapy of vitamin B1combined with alprostadil．

       

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