Abstract: Objective: To investigate the effects of interleukin-10 (IL-10),tumor necrosis factor-α (TNF-α),and transforming growth factor-β (TGF-β) in pathogenesis and aggravating phase of chronic obstructive pulmonary disease (COPD).Methods: The serum contents of IL-10,TNF-α and TGF-β in acute exacerbation,catabasis phases of COPD and health control group were determeined by enzyme linked immunosorbent assay.Results: The levels of serum IL-10 in acute exacerbation and catabasis phases of COPD were lower than in normal control group (P<0.01);the levels of serum TNF-α of in acute exacerbation and catabasis phases of COPD were significantly higher than in normal control group (P<0.01);the content of serum TGF-β in acute exacerbation phase of COPD was higher than in normal control group and COPD catabasis group,but there was no significant difference between COPD catabasis phase and normal control group (P>0.05).TGF-β was positively correlated with IL-10 in COPD acute exacerbation phase.Conclusions: IL-10,TNF-α and TGF-β are all involved participate in the procedure of COPD pathogenesis and aggravating phase.The content of serum IL-10 in COPD is depressed,which maybe plays an important role in inflammatory reaction and aggravating phase of COPD.