Abstract: Objective:To observe the value of determining the serum levels and C-reactive protein (CRP) in diagnosis and prognosis of acute pancreatitis (AP).Methods:According to the results of Ranson score and CT grades,33 patients were classified into mild acute pancreatitis group (15 cases),severe acute pancreatitis group (18 cases),SAP with complication group (4 cases) and SAP without complication group (14 cases).The Serum levels of all the patients were determined with full automatic biochemistry analyzer on day 1,3,7 and 14 of admission,and 12 healthy people acted as control.Results:The CRP in AP patients was significantly higher than that of the normal control at admission (P<0.01).The CRP was significantly higher in the severe AP group than in the mild AP group,and the CRP in SAP with complication group was significantly higher than that without complication group one week after admission (P<0.01).The serum value of CRP in the SAP groups reached the peak on the third day after onset.Conclusions:Dynamic changes of the serum levels of CRP are related to the occurrence and development of AP;the serum levels of CRP may act as a predictive index in diagnosis and prognosis of acute pancreatitis.