Abstract: Objective: To explore the distribution,types and drug resistance of pathogenic bacteria of burn patients,and guide the rational use of antibiotics.Methods: Forty-seven blood and wound excreta samples were collected from 27 severe burn patients treated between Jan.2005 and Nov.2007.The pathogenic bacteria were cultured for detection of drug sensitivity.Results: Pathogenic bacteria were detected in 43 samples,and the detection rate was 91.2%.The total detected bacteria belonged to 10 species and 52 strains.Among them,22 strains were G⁺ bacteria and 30 were G^- bacteria.Pseudomonas aeruginosa was ranked the first in G^- bacteriums and Staphylococcus aureus was ranked the first in G⁺ bacteriums.Drug sensitivity test indicated that 10 species of pathogenic bacteria showed different extend drug resistance to 12 commonly used antibiotics.Staphylococcus aureus showed drug resistance to 9 antibiotics but 100% sensitivity to vancocin.Aeruginosus bacillus kept higher resistance rate to the third and fourth generation cephalosporins and meropenem.Conclusions: Pseudomonas aeruginosa and Staphylococcus aureus are the two most mainly pathogenic bacteria in the infection of burn patients.Dynamic observation of changes in pathogenic strains and sensitivty of bacteria to antibiotics are useful for clinical prevention and cure of burn infection.