大剂量丙种球蛋白治疗Guilain-Barre综合征的疗效观察

Effect of high dose of intravenous immunoglobulin on Guillain-Barre syndrome

摘要: 目的: 观察静脉滴注大剂量丙种球蛋白(IVIG)治疗Guilian-Barre综合征(GBS)的疗效。方法: 应用IVIG0.4g·kg^-1·d^-1连用5天,与同期应用激素冲击治疗的疗效进行比较。结果: 大剂量IVIG治疗GBS临床分级评分和见效时间均优于激素治疗组(P<0.05和P<0.001),但两组总有效率差异无显著性(P>0.05)。结论: 大剂量IVIG治疗GBS临床分级评分和见效时间均优于激素冲击组。

Abstract: Objective: To observe the therapeutic effect of high dose of intravenous immunoglobulin (IVIG) in treatment of Guillain-Barre syndrome (GBS).Methods: Eleven patients with GBS were treated with IVIG in a dose of 0.4 g·kg^-1·d^-1for 5 consecutive days,and the other 16 patients were treated with steroid.The therapeutic effect was compared.Results: The IVIG-treated group was superior to the steroid-treated group in cynical grading scale and time of response(P<0.05 and P<0.001),but there was no significant difference in the total effective rate.Conclusions: Treatment of Guilian-Barre syndrome with high dose of IVIG is superior to that with steroid in clinical grading scale and time of response.