Abstract: Objective: To explore the changes of serum COX-2,IL-8 and IgE levels in asthmatic children and their clinical significance.Methods: The serum COX-2,IL-8 and IgE levels of 121 asthmatic children,including 62 cases in the acute attack group and 59 cases in the remission group,and 60 healthy controls were detected by sandwich ELISA.Results: The serum COX-2,IL-8 and IgE levels in the asthmatic groups increased(P<0.05).The serum COX-2,IL-8 and IgE levels in the acute attack group were higher than those in the remission group(P<0.01);the serum COX-2,IL-8 and IgE levels in both acute attack group and remission group were higher than those in control group(P<0.01).Conclusions: COX-2,IL-8 may involve in the pathologeic process of asthmatic children,which may accelerate secretion of IgE from positive feedback regulation.Inflammatory reaction may still exist during the remission stage of asthma.The imbalance of cytokine network may probably be important reasons as a molecular basis in the asthma pathogenesis.The therapy of anti-COX-2 or cytokine network may relieve the condition of the asthma children.