Abstract: Objective: To discuss the clinic value of management of the premature infants.Methods: The clinical data of 98 premature infants were reviewed.Results: Ninty-eight cases have different degrees of complications,including hyperbilirubinemia,cold injury syndrome,pneumonia,apnea,hypoglycemia,hypocalcemia,intracranial hemorrhage,pulmonary hemorrhage,septicemia,purulent meningitis,and ventriculitis.Eighty-two cases have recovered from illness.Sixteen cases have died.Death rate is 16.33%.Death rate of fetal age less than 32 weeks was obviously higher than that of more than 32 weeks(P<0.01).Death rate of birth weight less than(1 500 g) was obviously higher than that of more than 1 500 g(P<0.05).The causes of death were mainly pulmonary hemorrhage,intracranial hemorrhage,pneumonia,septicemia and purulent meningitis.Conclusions: Distinguish early and treat correctly the complications of the premature infant is the main measure to reduce the death rate of the premature infant.