Abstract: Objective: To study the expression of cell division cycle 2 (CDC2) in breast carcinoma,and their associations with clinicopathological parameters and the relationship between CDC2 and C-erbB-2.Methods: Immunohistochemistry (EliVision) was used to detect the expression of CDC2 and C-erbB-2 in 60 cases of invasive breast carcinomas.Results: The positive expression of CDC2 in breast carcinoma was 61.7%.The expression of CDC2 was correlated with the histological grade (P<0.01),and there was a positive correlation between CDC2 and C-erbB-2 (P<0.01).Conclusions: High expression of CDC2 protein may play an important role in the pathogenesis and progression of breast carcinoma;CDC2 may advance the proliferation of cells.The expression of CDC2 and C-erbB-2 may be useful parameters in evaluating the biological behaviors of breast carcinoma.