Abstract: Objective: To explore the curative curative effects of regimens containing levofloxacin with varied courses on coal workers'pneumoconiosis-tuberculosis.Methods: The curative effects were compared between 51 patients receiving the treatment scheme of 6SHRZV/12HRE and 50 patients receiving the treatment scheme of 3SHRZV/9HRE.The comparision included the sputum negative conversion rates of tuberculosis-bacillus at the end of the 6-month treatment and the whole treatment,as welll as the chest X-ray improvement after the course of treatment.Results: There was significant difference between the two groups(the treatment scheme of 6SHRZV/12HRE and 3SHRZV/9HRE) in the sputum negative conversion rates of tuberculosis-bacillus(92.2%,78%,respectively) at the end of the whole treatment(P<0.05).There was significant difference between the two groups in the chest x-ray improvement after the course of treatment(P<0.05).Conclusions: According to the evaluation for the curative effects of regimens including levofloxacin,the treatment scheme of 6SHRZV/12HRE is appropriate to coal workers'pneumoconiosis-tuberculosis.