Abstract: Objective: To observe the effect of hemabate on patients with postpartum hemorrhage caused by uterine atony.Methods: Sixty-four patients with blood loss exceeding 400 ml within 2 hours after vaginal delivery or cesarean section due to uterine atony were randomly divide into control group and observation group.All the patients were routinely injected oxytocin 20 u to the uterine muscle after the baby was delivered.If the therapy did not work,the control group was given 20 u oxytocin intravenously,which might be repeated when necessary with a total volume ≤ 120 u,while the observation group was administered injection of hemabate 250 μg into the uterine,which might be repeated at 15 minutes intervals when necessary with a total volume ≤ 500 μg.Results: The total efficiency was 93.75% in the observation group,which was superior to that of 81.25% in the control group(P<0.01).Conclusions: Hemabate is effective on postpartum hemorrhage caused by uterine atony.It has the advantages of high efficiency,safity,light side effect and convenience.Correct diagnosis and early application are essential to achieve better results.