帕珠沙星氯化钠注射液治疗下呼吸道感染的临床研究

邓静; 李殿明; 陈余清; 黄礼年; 高华; 刘超; 胡俊锋

帕珠沙星氯化钠注射液治疗下呼吸道感染的临床研究

Pazufloxacin sodium chloride injection in treatment of lower respiratory infection

摘要

摘要: 目的: 观察帕珠沙星氯化钠注射液治疗下呼吸道感染的临床疗效与安全性。方法: 随机开放性研究帕珠沙星氯化钠注射液治疗下呼吸道感染,并与左氧氟沙星氯化钠注射液进行临床疗效比较。30例患者随机分为治疗组16例,给予帕珠沙星氯化钠注射液0.3 g静脉滴注,每天2次;对照组14例,给予左氧氟沙星氯化钠注射液0.4 g静脉滴注,每天2次;均治疗7~14天;评价其临床疗效及安全性。结果: 治疗组与对照组的用药天数分别为(8.74±2.28)天和(8.47±2.05)天(P>0.05);治疗组临床总有效率为93.75%,对照组为92.86%(P>0.05);两组一般资料差异均无显著性(P>0.05)。治疗期间未见明显与药物有关的不良反应。结论: 帕珠沙星氯化钠注射液治疗下呼吸道感染有效、安全,值得推广。

Abstract: Objective: To explore the clinical efficiency and safety of pazufloxacin sodium chloride injection in treatment of lower respiratory infection.Methods: The clinical effect of pazufloxacin on lower respiratory infection was observed and compared with that of levofloxacin.Thirty patients were randomly divided into treatment group(16 cases) and control group(14 cases) receiving pazufloxacin and levofloxacin,respectively,for 7 to 14 days.Results: Pazufloxacin and levofloxacin were used for (8.74±2.28) days and(8.47±2.05) days,respectively(P>0.05).The total response rates were 93.75% and 92.86% in the treatment group and control group,respectively(P>0.05).There was no side difference in common data between the two groups.During the course of treatment,no side effect related to the drug occurred.Conclusions: It is safe and effective to treat lower respiratory infection with pazufloxacin sodium chloride injection.

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