CD44v6和PTEN在肾癌中的表达及其临床意义

刘显河; 周文生

CD44v6和PTEN在肾癌中的表达及其临床意义

The expressions of CD44v6 and PTEN in renal cell carcinoma and its clinical significance

摘要

摘要: 目的:探讨CD44v6和PTEN基因在肾癌中的表达及意义。方法:用免疫组织化学S-P法检测60例肾细胞癌、20例癌旁肾组织、10例正常肾组织中PTEN、CD44v6的表达,并结合临床随访资料进行分析。结果:肾癌中CD44v6和PTEN阳性表达率分别为51.7%和66.7%。肾细胞癌分级、分期和淋巴结转移与CD44v6高表达和PTEN低表达均有一定关系(P<0.05~P<0.01);CD44v6表达与PTEN表达呈负相关关系(P<0.01)。结论:CD44v6高表达和PTEN低表达,对判断肾细胞癌恶性程度、预测淋巴结转移有一定的参考价值。

Abstract: Objective: To investigate the expressions of CD44v6 and PTEN in renal cell carcinomal (RCC) and its clinical significance.Methods: The expressions of CD44v6 and PTEN were examined by immunohistochemistry S-P method in 20 cases of Para carcinoma,10 cases of normal renal tissues and 60 cases of RCC;And the pathobiologic behavior was analyzed.Results: The positive rates of CD44v6 and PTEN in RCC were 51.7% and 66.7%,respectively.The histological grading,clinical staging and metastases potential of RCC were correlated with high expression of CD44v6 and low expression of PTEN (P<0.01).The expression of CD44v6 was negatively correlated with the expression of PTEN (P<0.05-P<0.01).Conclusions: The result suggests that high expression of CD44v6 and low expression of PTEN might be a useful indicator for evaluation of the differentiation of tumors and prediction of lymph nodes metastasis.

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