Abstract: Objective:To observe the effect of nursing intervention in one-time portable flexible infusion pump application.Methods:The observe group (30 cases) were treated with a daily injection;the length of the pump column was observed,measured and recorded every 3 hours;the remaining amount of drugs was calculated,and appropriate nursing care was given.The control group (30 cases) were treated with a one-time injection and given the routine nursing care.The accuracy of pump infusion and the adverse reactions after treatment were compared between the two groups.Results:The infusion time was more accurate and there was less phlebitis caused by medication in the observe group than in the control (P<0.01 and P<0.05).Conclusions:By taking positive and effective nursing intervention,the drugs can be safely,uniformly and accurately injected into the body,which may reduce the adverse reactions after treatment and improve patients' satisfaction degree.It is worth popularizing in clinical practice.