Abstract: Objective:To study the clinical therapeutic effect in patients suffered from Barrett's esophagus.Methods:Fifty-four patients who suffered from Barrett's esophagus were divided into three groups:control group,the group treated with drugs only and the group treated with argon plasma coagulation (APC) and drugs.The total remission rate,the changes of mucous membranes of Barrett's esophagus in endoscope and the adverse effect were studied in different groups.Results:The total remission rates in the group treated with drugs only and the group treated with APC and drugs were increased compared to control group (P<0.01).And the effect in group with APC and drugs was more significant than in group with drugs only.There was no conspicuous change of mucous membranes of Barrett's esophagus in control group and the group treated with drugs only,but mucous membranes were disappeared in the group treated with APC and drugs.No serious adverse effect was observed in the three groups.Conclusions:It is a safety and effective method to treat Barrett's esophagus with APC and drugs.