Abstract: Objective: To study the efficacy of medroxyprogesterone in endometriosis after conservative surgery.Methods: From 1997 to 2000,102 women with endometriosis received conservative surgery in our hospital.They were divided into two groups.Group A(n=47) were treated with medroxyprogesterone(200 mg/d.Po) for six months.Group B(n=55) were for control.Relief and recurrent rates were analyzed six months and two years after surgery respectively.Results: The six-month symptom relief rates of the two groups were 100% and 81.8%,respectively(P<0.01).The sign relief rates of the two groups were 97.8% and 81.8%,respectively(P<0.01).The two year recurrent rates of the two groups were 8.5% and 23.6%,respectively(P<0.05).The level of alanine aminotransferase(ALT) increased in 2 of the 47 cases.Eleven of the 47 cases had nausea or vomiting.Conclusions: Using medroxyprogesterone after consevative surgery for endometriosis can reduce the recurrent rates.