Abstract: Objective: To explore the incidence of post-stroke depression and its related factors in the young and middle aged people. Methods: Ninety-six patients with cerebral stroke in the young and middle-aged people were investigated by using HAMD and Chinese scale of clinical neurologic deficit. The related factors such as the location and quantity of lesions, complication, sex and culture background were analyzed with the statistical method. Results: Incidence of post-stroke depression in the young and middle-aged people was about 36.46%. It was not related with sex, culture background, profession, the location of lesions, the clinical neurological deficit and the activity of daily living (P>0.05). But it was related with the hobby of tobacco and alcohol, and complicating hypertension (P<0.05-P<0.005). Conclusions: The post-stroke depression is the common complication after stroke in the young and middle-aged people. It directly affects the prognosis of stroke. The early prevention, diagnosis and treatment of post-stroke depression should be emphasized.