Abstract: Objective:To investigate the clinical features and prognosis of clinically amyopathic dermatomyositis(CADM). Methods:The clinical data including the skin lesion,muscle involvement and pathological changes of the lung in 10 patients with CADM were analyzed retrospectively. Results:All the 10 patients presented characteristic skin lesions such as Gottron, S papulae (9 cases), heliotropic periorbital erythrema(8 cases), V-sign rash (10 cases) and shawl-sign rash (5 cases). Interstitial lung disease (ILD) occurred in 9 patients,and 4 of them died of respiratory failure resulting from rapidly progressive ILD. Conclusions:ILD is the most common and severe complication leading to mortality in CADM patients; therefore it should be highly alerted to and properly managed.