Abstract: Objective: To investigate the clinical features,early diagnosis and treatment of special-site ectopic pregnancy(SEP).Methods: The clinical data of 16 cases with SEP were reviewed.Results: The SEP in the study included cornual pregnancy,interstitial tubal pregnancy,varian pregnancy,cervical pregnancy,abdominal pregnancy and rudimentary horn of uterus pregnancy.The incidence of SEP accounted for 4.90% of the ectopic pregnancy and the main clinical symptoms of SEP were abdominal pain,menopause and vaginal bleeding.All the cases (16 cases) were treated by surgery,and the prognosis was good.Conclusions: SEP causes acute abdomen pain and damages the health of pregnant woman greatly.The clinical manifestations of SEP in the early period are atypical.Once the diagnosis is made,surgery should be performed immediately.