Abstract: Objective: To investigate the effect of domperidone combined with doxepin on functional dyspepsia.Methods: One hundred and twenty patients with functional dyspepsia were randomly divided into 2 groups.Domperidone 10 mg was given 3 times per day and doxepin 50 mg per night to the therapeutic group,and domperidone 10 mg 3 times per day to the control group for 4 weeks.The symptom scores were measured before and 4 weeks after treatment.The effective index was calculated 4 weeks after the treatment.Results: The difference between the mean total symptom scores of the therapeutic group and control group before treatment was not significant(P>0.05).The total symptom scores of the two groups decreased significantly 4 weeks later,and the difference was significant in patients receiving domperidone combined with doxepin(P<0.01).The effective rate of medical group was significantly higher than that of the control group(P<0.01).Conclusions: Domperidone combined with doxepin is significantly effective in the treatment of functional dyspepsia.