Abstract: Objective: To strengthen the transfusion management of cryoprecipitate in clinical use and apply cryoprecipitate to reasonable patients in order to decrease occurrence of diseases which spread by transfusion and reduce abnormal transfusion reaction. Methods: The amounts of cryoprecipitate(units) that had been applied in the first affiliated hospital of Bengbu Medical College from 2008-2010 years and the cases in 2010 year were statistical analyzed. The reasonable use rate of cryoprecipitate and the unreasonable use rate were counted. Results: The annual average amounts of cryoprecipitate that had been applied in the years 2009 and 2010 were 3.4 times as many as in the year 2008. The reasonable use rate of cryoprecipitate was 43.8% and the unreasonable use rate was 56.2% in the year 2010. Conclusions: The amounts of cryoprecipitate that had been applied in the first affiliated hospital of Bengbu Medical College were excessive in the years 2009 and 2010. the unreasonable use rate of cryoprecipitate was high in the year 2010. So the transfusion management of cryoprecipitate should be strengthened in clinical uses,and the suitable cases should be strictly choosen and unnecessary transfusion of cryoprecipitate should be stopped.