Correlation between coagulation function, platelet parameters and preeclampsia

ObjectiveTo analyze the coagulation function index and platelet parameters of patients, and explore their clinical significance in preeclampsia (PE).

MethodsSeventy-eight pregnant women with PE were set as the observation group, and subdivided into the observation group 1 (early PE group, 20 weeks ≤gestational weeks < 34 weeks) and observation group 2 (late PE group, onset ≥34 weeks).At the same time, 80 healthy pregnant women were set as the control group, and subdivided into the control group 1 (20 weeks ≤gestational weeks < 34 weeks) and control group 2 (onset ≥34 weeks).The blood of all cases was collected, and the blood pressure was measured.The indicators of coagulation function and platelet parameters were detected.The correlation between D-dimer (D-D) and coagulation function indexes were analyzed using the Pearson test.

ResultsThe body mass index (BMI), D-D, systolic pressure (SBP), diastolic pressure (DBP), mean platelet volume (MPV) and platelet distribution width (PDW) in observation group 1 were higher than those in control group 1 (P < 0.01).The BMI, SBP and DBP in observation group 2 were higher than those in control group 2 (P < 0.01).The D-D in observation 1 group was higher than that in observation group 2 (P < 0.01).The levels of BMI, D-D, DBP and MPV in control group 2 were higher than those in control group 1 (P < 0.05 to P < 0.01).The levels of BMI, D-D, SBP, DBP and MPV in observation group were higher than those in control group (P < 0.01).The differences of the levels of PT, INR, APTT, FIB and TT between the observation group 1 and control group 1 were statistically significant (P < 0.05 to P < 0.01).The differences of the levels of PT, INR, FIB and TT between the observation group 2 and control group 2 were statistically significant (P < 0.01).The difference of the level of TT between the observation group 1 and observation group 2 was statistically significant (P < 0.05).The differences of the levels of FIB and TT between the control group 1 and control group 2 were statistically significant (P < 0.01).The differences of the levels of PT, INR, APTT, FIB and TT between the observation group and control group were statistically significant (P < 0.01).The D-D in PE patients was negatively correlated with the levels of gestational weeks, PT, INR, APTT, and TT (r=-0.289, -0.235, -0.247, -0.236, -0.351, -0.286, P < 0.05 to P < 0.01), and the D-D was not correlated with the levels of FIB, MPV, and PDW in PE patients (P>0.05).

ConclusionsThe high coagulation status in early PE patients is more obvious than that in late PE patients.The D-D in PE patients is closely related to coagulation function, and the D-D can be used as a biological marker to predict the incidence of PE.