Effect of nanometer silver dressing combined with epidermal growth factor gel on the wound dissolved scab and healing of deep Ⅱ degree burn

Objective To analyze the effects of nanometer silver dressing combined with epidermal growth factor gel on the wound treatment of deep Ⅱ degree burn.

Methods One hundred and fifty-six patients with deep Ⅱ degree burn were randomly divided into the observation group and control group by digital table method (78 cases in each group).After the debridement, the observation group was treated with nanometer silver dressing combined with epidermal growth factor gel, and the control group was treated with epidermal growth factor gel.The wound surface condition was observed at changing the dressing.The visual analogue scale (VAS) of wound before and after 1 week of treatment, scab solubility of wound surface after 1, 2, 3 and 4 weeks of treatment, positive rate of bacterial culture, time of completing dissolution and healing time of wound were compared between two groups.The expression levels of matrix metalloproteinase-1 and 2 (MMP-1 and MMP-2) in two groups before and after 2 weeks of treatment were detected using immunohistochemistry.The incidence rates of adverse reactions before and after treatment were recorded.

Results In the observation group, the wound scab skin became soft on the 4th day, most of the scab shell fell off on the 6th day, and the wound scab skin basically dissolved on the 8th day.In the control group, the dry scab wound formed on the 4th day, the wound became dry on the 6th day, some necrotic tissues were yellowish black, but not yet shed, the dry scab gradually softened on the 8th day, and the dry scab gradually fell off and basal granulation tissue grew on the 10th day.After treatment, the VAS scores in two groups were significantly lower than that before treatment (P < 0.01), and which in observation group was significantly lower than that in control group (P < 0.01).The wound dissolving rates in observation group at 1 and 2 weeks after treatment were significantly higher than that in control group (P < 0.01).The dissolution time and wound healing time in observation group were significantly shorter than those in control group (P < 0.01).The positive rate of bacteria in observation group (11.54%) was significantly lower than that in control group (24.36%) (P < 0.05).Compared with before treatment, the expression levels of MMP-1 and MMP-2 in two groups significantly decreased, and which in observation group were significantly lower than those in control group (P < 0.01).

Conclusion The nanometer silver dressing combined with epidermal growth factor gel in the treatment of the wound of deep Ⅱ degree burn has high dissolving rate of scab and short wound healing time, the mechanism of which may be related to the expression inhibition of MMP-1 and MMP-2 in wounds.