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    WANG Li-ping, WANG Qi-zhi, DENG Min, YAN Shan-jun, WANG Qiang-wu, LI Da-peng, WANG Jian-chao. The expression of microRNA-100 in gastric cancer and its clinical significance[J]. Journal of Bengbu Medical University, 2015, 40(1): 37-39,42. DOI: 10.13898/j.cnki.issn.1000-2200.2015.01.012
    Citation: WANG Li-ping, WANG Qi-zhi, DENG Min, YAN Shan-jun, WANG Qiang-wu, LI Da-peng, WANG Jian-chao. The expression of microRNA-100 in gastric cancer and its clinical significance[J]. Journal of Bengbu Medical University, 2015, 40(1): 37-39,42. DOI: 10.13898/j.cnki.issn.1000-2200.2015.01.012
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    The expression of microRNA-100 in gastric cancer and its clinical significance

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    • Objective:To detect the expression of microRNA-100(miRNA-100) in gastric cancer and its relation with clinicopathologic features.Methods:The total RNA in 50 gastric cancer tissue specimens and non-tumor adjacent tissue specimens were extracted, the expression levels of miRNA-100 were detected by TaqMan real-time quantitative PCR assay.The correlations of miRNA-100 expression and differentiation and lymph node metastasis of gastric cancer were analyzed.Results:The expression levels of miRNA-100 in gastric carcinoma tissue and normal gastric tissue were 1.31±0.69 and 0.74±0.36, respectively, the difference of which was statistical significance(P<0.01).The differences of miRNA-100 expressions in age, gender, tumor location, tumor size, degree of differentiation, lymph node metastasis and TNM staging were not statistically significant(P>0.05).Conclusions:The abnormal expression of miRNA-100 may be associated with the occurrence of gastric cancer.
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