The correlation of the level of plasma homocysteine and subcortical small vessel disease

Objective:To study the relationship between the level of plasma homocysteine(Hcy) and subcortical small vessel disease(SVD), and the clinical significance.Methods:The levels of plasma Hcy in 90 cases with cerebral SVD(including lacunar infarction and white matter lesion) diagnosed by MRI(SVD group) and 90 hospitalized patients without SVD(control group) were compared.Results:The levels of plasma Hcy in SVD group were significantly higher than those in control group(P<0.01).Conclusions:The level of plasma Hcy increasing is an independent risk factor of cerebral SVD.