Analysis of coagulation function biomarkers and D-dimers in late pregnant women

Objective: To study the clinical significance of prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(Fbg) and D-dimers(D-D) in the plasma of late pregnant women.Methods: The blood coagulation function markers and D-D in 360 late pregnant women and 80 non-pregnant healthy people were determined by Sysmex CA-7000 auto coagulation analyzer.Results: The levels of PT,APTT,TT,Fbg and D-D in the plasma of late pregnant women were respectively(9.44±0.90)s,(29.86±6.20)s,(13.41±1.86)s,(3.28±0.87)g/L and (1.08±2.23)mg/L,while the levels of these markers were respectively (12.24±1.08)s,(30.18±3.19)s,(16.31±1.03)s,(2.55±0.53)g/L and (0.27±0.08)mg/L in the control.Compared with the control group,the levels of PT and APTT in the late pregnant women significantly decreased(P<0.01),and the levels of Fbg and D-D obviously increased(P<0.01).Conclusions: Gestational age-specific reference values are essential for accurate interpretation of a subset of haemostatic tests during pregnancy,delivery and puerperium.The markers of blood coagulation function and D-D in late pregnant women should be timely determined before delivery in case of abnormal bleeding or disseminated intravascular coagulation.