Effect of recombinant human growth hormone combined with branched chain amino acid on the levels of tumor necrosis factor-α and interleukins-10 in patients with hepatic cirrhosis

Objective:To investigate the effects of recombinant human growth hormone(r-hGH) combined with branched chain amino acid(BCAA) on the levels of Tumor necrosis factor-α(TNF-α) and interleukins-10(IL-10) in patients with decompensated cirrhosis.Methods:Eighty-two patients with decompensated cirrhosis were randomly divided into the treatment group(42 cases) and control group(40 cases).The treatment group and control group were treated with 5 IU of r-hGH by subcutaneous injection 1 time two days combined with 250 ml of BCAA by intravenous drip once a day for 20 d and 250 ml of BCAA by intravenous drip once a day for 20 d based on protecting liver and support treatment,respectively.The liver function and levels of TNF-α and IL-10 in two groups were observed before and after treatment.Results:The liver function and levels of TNF-α and IL-10 in two groups were improved,the improvement of poor appetite,lower limbs edema,and the levels of alanine aminotransferase,albumin,TNF-α and IL-10 in treatment group were better than those in control group(P<0.05 to P<0.01).Conclusions:The effects of r-hGH combined with BCAA on the improvement of serum albumin,TNF-α and IL-10 levels are better than those of BCAA alone.