Clinical characteristics and survival analysis of triple-negative breast cancer in 90 cases

Objective:To analyze the clinical data of 90 cases with triple negative breast cancer(TNBC) in order to investigate its clinicopathologic characteristics and prognostic factors.Methods:The clinical data of 284 patients with breast cancer diagnosed by histopathology were collected.The clinicopathologic characteristics, recurrence and metastasis of TNBC were retrospectively analyzed by statistical software.Results:Among 284 breast cancer patients, 90 cases were TNBC, and were followed up for 12-84 months.The age of TNBC patient was young than that of n-TNBC patient(P<0.01), the tumor size in TNBC patient was larger than that in n-TNBC patients(P<0.01).The metastasis rate of axillary lymph node was high.The recurrence and metastasis in 82 cases of TNBC patients were found, the recurrence and distance metastasis in TNBC patients was more than that in n-TNBC patient(P<0.01).The metastases in liver, lung and brain in TNBC patients were more than those in n-TNBC patients(P<0.01).The survival analysis showed than the 5-year disease free survival and overall survival in TNBC group and n-TNBC group were 3.3% ＆ 71.1% and 4.6% ＆ 84.5%, respectively.The results of univariate analysis showed that age, family history, histological grade, tumor size, the number of lymph node metastasis, and adjuvant radio and endocrine therapy affected the recurrence, metastasis and prognosis of TNBC and n-TNBC patients.Multivariate analysis showed the age, histological grade, tumor size, the number of axillary lymph nodes metastasis were independently effective factor in the recurrence, metastasis and prognosis of TNBC patients.Conclusions:Compared with the n-TNBC patients, the TNBC patient is young, nonmenopause, high recurrence and metastasis after surgery(more in liver and bone) and low 3- and 5-year overall survival and disease free survival rates.