The levels of IL-6,IL-8 and IL-10 in serum and bronchoalveolar lavage fluid in patients with community-acquired pneumonia and its clinical significance

Objective:To explore the levels of IL-6, IL-8 and IL-10 in serum and bronchoalveolar lavage fluid(BALF) of patients with community-acquired pneumonia(CAP), and its clinical significance.Methods:The clinical pulmonary infection score of 50 patients with CAP were detected on the first day after admission.The patients with CPIS less than 6 and equal to or more than 6 were divided into the light group and severe group, respectively.Ten healthy people were set as the control group.The levels of IL-6, IL-8 and IL-10 in serum and BALF of the patients with CAP were determined by radioimmunoassay on the first day after admission.The levels of IL-6, IL-8 and IL-10 in serum of the patients with CAP were also measured on day 7 and 30 of admission.Results:The levels of IL-6, IL-8 and IL-10 in serum and BALF of CAP patients were significantly higher than those in control group on the first day after admission(P<0.05 to P<0.01).The levels of IL-6 and IL-10 in serum and levels of IL-6, IL-8, IL-10 in BALF in severe CAP group were significantly higher in light CAP patients(P<0.01).With the disease course prolonging, the levels of IL-6 and IL-10 decreased(P<0.01), which arrived at the level of the control group on day 7 and 30 of admission(P>0.05).The level of IL-8 in serum of CAP patients remained at a high level on day 30 of admission, which was significantly higher than that in control group(P<0.01).Conclusions:The IL-6, IL-8 and IL-10 were involved in the pathogenesis of community-acquired pneumonia.The levels of IL-6 and IL-10 in serum and levels of IL-6, IL-8 and IL-10 in BALF can reflect the severity of pulmonary infection.The detection of IL-6, IL-8 and IL-10 in serum has certain clinical value in the early diagnosis of CAP.