Curative effects analysis of using rosuvastatin calcium combined with clopidogrel to treat unstable angina pectoris

Objective:To explore the curative effects and clinical safety of rosuvastatin calcium combined with clopidogrel in the treatment of unstable angina pectoris(UAP).Methods:One hundred and twelve patients with UAP were divided into the control group(44 cases) and observation group(68 cases) according to different therapeutic methods.The control group and observation group were treated with low molecular heparin, aspirin, angiotensin converting enzyme inhibitors, nitrates and beta blockers and rosuvastatin calcium combined with clopidogrel based on the control group treatment, respectively.The clinical curative effects, safety, blood lipid level and adverse reactions in two groups were monitored.Results:The total effective rate in observation group(94.1%) was higher than that in control group(81.8%) (P<0.05).The effective rate of electrocardiogram improvement in observation group(92.6%) was significantly higher than that in control group(77.3%) (P<0.01).The difference of the blood lipid level between two groups before treatment was not statistically significant (P>0.05), the blood lipid level in observation group after treatment was improved(P<0.01), and the difference of the blood lipid level between two groups after treatment was statistically significant (P<0.01).The incidences of adverse reactions in control group and observation group were 2.9% and 13.6%, respectively, the difference of which was not statistically significant (P>0.05).During the following-up period, the angina recurrence rate in observation group were lower than those in controll group(P<0.05).Conclusions:On the basis of conventional treatment, the rosuvastatin calcium combined with clopidogrel in the treatment of unstable angina pectoris has good effects and high safety, which is worthy of clinical application.