The effect of different doses of atorvastatin on cardiac function and lipid in the patients with coronary heart disease after coronary artery bypass grafting

Objective:To explore the effects of different doses of atorvastatin on the cardiac function and lipid in the patients with coronary heart disease after coronary artery bypass grafting(CABG).Methods:Sixty patients with coronary artery disease scheduled by CABG were randomly divided into the intensive treatment group(40 mg/d) and conventional treatment group(20 mg/d) according to the dose of atorvastatn before and after the surgery(30 cases each group).The blood lipid level and echocardiographic finding between two groups were compared before and after surgery, and the adverse reactions in two groups were recorded during treatment.Results:After treatment, the reduction of total cholesterol, triglyceride and low-density lipoprotein-cholesterol and increasing degree of high-density lipoprotein-cholesterol in intensive treatment group were better than those in conventional treatment group(P<0.05 to P<0.01).After treatment, the reduction of left ventricular end systolic volume index, left ventricular end-diastolic volume index and A peak and increasing degree of E peak, E/A and left ventricular ejection fraction in intensive treatment group were better than those in conventional treatment group(P<0.01).The adverse reaction rates in intensive treatment group and conventional treatment group were 16.67% and 10.00%, respectively, the difference of which was not statistically significant(P>0.05).Conclusions:The application of atorvastatin in the treatment of the coronary heart disease patients treated with CABG before and after surgery can significantly regulate blood lipid and improve heart function, which does not increase adverse reactions, and is safe and effective.