Change of lymphocyte subsets in children with idiopathic thrombocytopenic purpura

Objective:To explore the changes of lymphocyte subsets in children with idiopathic thrombocytopenic purpura(ITP).Methods:The changes of lymphocyte subsets in 85 patients with ITP and 33 heathy people were detected by flow cytometry.Results:The percentages of CD3⁺ and CD4⁺ and the ratio of CD4/CD8 in ITP group were lower than those in control group(P<0.01), and the difference of CD8⁺ lymphocyte between two groups was not statistically significant(P>0.05).Compared with the control group, the number of CD19⁺ and CD16⁺CD56⁺ lymphocytes in ITP group increased and decreased, respectively, the differences of whose between two groups were statistically significant(P<0.01).Conclusions:The disorder of lymphocyte subsets is one of the immune mechanism of ITP occurrence in children.Correcting disorder will be conducive to the treatment.