Comparision of anticoagulative effect between argatroban and heparin during the continuous veno-venous hemofiltration

Objective:To compare the anticoagulative effects and safety between argatroban and heparin in continuous veno-venous hemofiltration(CVVH) therapy.Methods:Forty renal insufficiency patients were randomly divided into the argatroban group and heparin group(20 cases each group).The argatroban group and heparin group were treated with argatroban and heparin,respectively.The platelet(PLT) and renal function before and after treatment,and activated partial thromboplastin time(APTT)after 1,4 and 8 h of the beginning of treatment,before the end of treatment and after 1h of treatment were detected.The blood coagulation of pipe and filter during treatment,and bleeding after 24 h of the end of treatment were observed.Results:Compared with before treatment,the number of PLT in heparin group decreased dramatically(PP>0.05).The differences of APTT between argatroban group and heparin group after CVVH and before the end of treatment were statistically significant(PP>0.05),but for heparin group,the APPT was still higher than that before treatment(PPP>0.05).Conclusions:The anticoagulative effect of argatroban in CVVH treatment is similar to the heparin,the recovery of CVVH is quick after stopping drug.The argatroban is good effect and high safety,which maybe an ideal anticoagulant in CVVH treatment.