Clinical analysis of fungemia in 42 preterm infants

Objective:To explore the clinical features of preterm infants with fungal infection to improve the early diagnosis and treatment.Methods:The maternal pregnant history,neonatal birth history,clinical manifestation,labaratory examination and treatmnet outcome data of 42 preterm infants with fungemia were retrospectively analyzed.Results:Among 42 preterm infants,38 cases with equal to and less than 34 weeks gestational age and 25 cases with equal to and less than 1 500 g weight were found.The frequent apnea in 16 cases,grey skin in 11 cases,feeding intolerance in 8 cases and unexplained condition deteriorated rapidly in 13 cases were identified.The use antibiotics more than 10 days in 32 cases,intravenous nutrition in 35 cases and peripherally inserted central catheter in 18 cases were the morbidity factors.The laboratory test showed that thrombocytopenia decreased 45.2%,and CRP increased 38.1%.Conclusions:Little gestational age,low body mass,The antibiotics use,intravenous nutrition and peripherally inserted central catheter are the high risk factors in fungal infection of preterm infants.The clinical manifestations of fungal infection in preterm infants are atypical,which need to attach great importance to early diagnosis and timely treatment.