Curative effect and clinical safety of azithromycin in the treatment of respiratory tract infection in children

Objective:To explore the curative effects and clinical safety of azithromycin(AZM) in the treatment of respiratory tract infection in children.Methods:One hundred and forty children(age≤10 years old) with acute bacterial respiratory infection were randomly divided into the observation group and control group(70 cases each group) using random number method.The observation group and control group were treated with AZM and cefuroxime sodium,respectively.The change of the clinical signs before and after treatment,clinical curative effects,clearance of pathogens and clinical safety in two groups were recorded and compared.Results:The disappearance time of fever,cough,short breath and lung sound in observation group were significantly shorter than those of in control group(PP>0.05).The difference of the clearance rate of pathogenic bacteria between the observation group(85.7%) and control group(80.6%) was not statistically significant(P>0.05).The drug susceptibility test results showed that the pathogen sensitive rates of AZM,cefuroxime sodium,erythromycin and penicillin were 90.9%,87.9%,68.2% and 45.5%,respectively.The difference of the pathogen sensitive rates between AZM and cefuroxime sodium was not statistically significant(P>0.05) while their pathogen sensitive rates were higher than those of erythromycin and penicillin(PPConclusions:The treatment of respiratory tract infection in children with azithromycin is good effects,short course,smaller dose and wider antimicrobial spectrum,and which is worthy of clinical promotion.