The correlation research of serum endothelin-1 and brain natriuretic peptide levels in heart failure patients

Objective:To observe the changes of serum endothelin-1(ET-1) and brain natriuretic peptide(BNP)levels in heart failure patients and explore the correlations.Methods:One hundred and twenty cases with heart failure were selected as observation group and 80 healthy persons as control group.Serum ET-1 and BNP levels were compared between the two groups.ET-1 and BNP levels in different New York heart association(NYHA) gradation patients were also recorded and their correlation with the degree of heart failure was explored.Results:Serum ET-1 and BNP levels in observation group were much higher than those in control group(PPPPConclusions:Serum ET-1 and BNP levels were greatly increased in heart failure patients,and closely related to disease severity.They can be the predictive indexes for evaluating disease condition and prognosis.