Effect of oxaliplatin and mannitol injection combined with raltitrexed in the treatment of advanced gastric cancer in elderly

Objective:To observe the effects and safety of oxaliplatin and mannitol injection combined with raltitrexed in the treatment of advanced gastric cancer.Methods:Forty-two elderly patients with advanced gastric cancer were randomly divided into the treatment group and control group(21 cases each group).The treatment group were treated with 130 mg/m² of oxaliplatin and mannitol injection combined with 3 mg/m² of raltitrexed by intravenous drip,the control group were treated with 100 mg/m² of cisplatin injection by intravenous drip combined with 1 000 mg/m² of capacitabin by oral,twice a day.The clinical effects and adverse reactions between 2 groups after two courses(21 days each course) were compared.Results:The total effect rates in treatment group and control group were 52.4% and 42.9%,respectively,the difference of which was not statistically significant(P>0.05).The incidences of grade Ⅰ-Ⅱ and Ⅲ-Ⅳ adverse reactions in treatment group and control group were 61.9% & 38.1% and 28.6% & 71.4%,respectively,the differences of whose were statistically significant(P<0.05).Conclusions:The treatment of advanced gastric cancer in elderly with oxaliplatin and mannitol injection combined with raltitrexed is less adverse reactions,and easy to tolerate.