The clinical application of inspiratory capacity in evaluating the therapeutic effect of patients with acute exacerbation of chronic obstructive pulmonary disease

Objective:To investigate the relationship between the inspiratory capacity(IC) and Borg score,hospitalization time and cost in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD),and provide the basis in evaluating the clinical effects.Methods:The 84 AECOPD patients with improvement rate ≥12% or increasing 200 ml of △IC,and <12% or increasing <200 ml were divided into the control Ⅰ group and observation group.The patients treated with continual treatment using the original scheme or combined with 18 μg/d of tiotropium were divided into the control Ⅱ group and Ⅲ group,respectively.The pulmonary ventilation function and lung capacity,Borg score,blood gas analysis,hospitalization time and cost in all patents were analyzed after 1 and 3 d of admission and before discharge.Results:After 3 d of admission and before discharge,IC in 3 groups were than that in the first day after adnission(P<0.05 to P<0.01),and the IC in Ⅰ group was significantly higher than that in the third day after admission(P<0.01).The differences of the Borg score,FEV1 and IC/TLC in 3 groups,and the difference of the △FEV1/FVC between Ⅰ and Ⅲ group were statistically significant(P<0.05 to P<0.01).The △PaCO₂ in Ⅲ group before discharge was lower than that in the third day after admission(P<0.05).The differences of the △FEV1/FVC in Ⅱ group,FRC and PaO₂ in 3 groups and the PaCO₂ between Ⅰ and Ⅱ group were not statistical significance(P>0.05).The hospitalization time and cost in Ⅰ,Ⅱ and Ⅲ group were 7 d & 6 800 yuan,11 d & 10 600 yuan and 9 d & 8 700 yuan,respectively.Among the 3 groups in the third day of admission and before discharge,the △ IC in 3 groups were negatively correlated with the △Borg score.hospitalization time and cost(P<0.05),and the △IC/TLC and △FEV1 were not correlated with the △Borg score(P>0.05).Among the 3 groups in the third day of admission and before discharge,the △FRC and △PaO₂ were negatively correlated with the hospitalization time(P<0.05),and the △PaCO₂ were positively correlated with the hospitalization cost(P<0.05),the △IC/TLC was negatively correlated with the hospitalization cost(P<0.01),the △PaO₂ and △PaCO₂ were positively correlated with the hospitalization cost(P<0.01),and the △FEV1 and △FEV1/ FVC were not correlated with other factors(P>0.05).Conclusions:Inspiratory capacity can evaluate the patients with acute chronic obstructive pulmonary disease before and after treatment,which is conducive to judge the clinical effects and formulate the treatment plan.