The sedative effect and safety of the compound anesthesia of midazolam-fentanyl during the painless detection of electronic bronchoscopy

Objective:To evaluate the sedative effects and safety of the compound anesthesia of midazolam-fentanyl during the detection of electronic bronchoscopy.Methods:One hundred and four patients detected by the electronic bronchoscopy were randomly divided into the midazolam-fentanyl group(A group) and conventional group(B group)(52 cases each group).The 2% lidocaine spraying nasal and throat surface for 4 times,and 0.9% saline infusion(dripping speed of 1.5 ml/min) were used in all patients before check.Before 5 min of check,the 3.0 mg midazolam combined with 50 μg fentanyl and 5 ml 0.9% saline infusion were slowly injected into A group and B group,respectively.Two groups were detected after 2 min of using drug.The systolic blood pressure(SBP),mean arterial pressure(MAP),breathing(RR),heart rate(HR) and blood oxygen saturation(SpO₂) before using drug(T₀) and after 2 min(T₁),5 min(T₂),10 min(T₃),15 min(T₄) and 30 min(T₅) of medication in two groups were recorded,and the cough,nausea,vomiting,breath control,interrupt checking and bad memories in two groups were observed.Results:Among A group,the SBP at T₁ to T₃,and MAP & HR at T₁ to T₄ were lower than those at T₀(P<0.05 to P<0.01),and the differences between the SBP at T₅,MAP and HR at T₁ to T₄ and RR at T₁ to T₅ and those at T₀ were not statistical significance(P>0.05).The MAP and HR at T₁ to T₄ in B group were higher than those at T₀ in B group and A group(P<0.05 to P<0.01).Compared with T₀,the SpO₂ in two groups decreased(P<0.01),but the SpO₂ at T₁ to T₄ in B group were lower than those in A group(P<0.01).The incidence rates of choke,cough,nausea,vomiting,bad breath and memory in B group were higher than those in A group(P<0.05 to P<0.01),The check in 8 cases of B group were interrupted by the excessive stimulus.Conclusions:The compound anesthesia of midazolam-fentanyl is an ideal clinical sedation drug in patients detected by the electronic bronchoscopy.