Clinical effect of the dinoprostone on induced labor in high risk pregnancy

Objective: To explore the safety and efficacy of dinoprostone on induced labor in high risk pregnancy.Methods: One hundred and twenty-six pregnant women with the indications of induced labor were randomly divided into the research group(controlled release dinoprostone suppository group) and control group(oxytocin group).The cervical ripening,success rate of induced labor,time from drug to labor,labor and hospital stay,delivery method and outcome in two groups were observed.Results: Compared with before treatment,the cervical score in research group increased significantly after treatment(P<0.01),the cervical ripening total effective rate was 92.1%.Compared with before treatment,the cervical score in control group increased after treatment(P<0.01),the cervical ripening rate was 44.4%.The difference of the total effective rate between two groups was statistically significant(P<0.01).The effects of induced labor showed that 80.9% pregnant women in research group and 15.9% pregnant woman in control group were in labor within 24 h,respectively,the difference of which was statistically significant(P<0.01).The vaginal delivery rate in research group(79.4%) was significantly higher than that in control group(47.6%)(P<0.01),the amount of postpartum haemorrhage in research group was significantly less than that in control group(P<0.01).The differences of birth 1 min Apgar score,newborn body quality and umbilical arterial blood pH value between two groups were not statistically significant(P>0.05).Conclusions: Dinoprostone treatment is continuity,slow-releasing and contractible renaturation.The induced labor with dinoprostone is suitable for high-risk pregnant women with cervical Bishop score equal to or less than 5,which is simple and safe.