Efficacy of early intelligence intervention combined with monosialotetrahexosylganglioside sodium treatment on rehabilitation outcome of neonatal hypoxic-ischemic encephalopathy

Objective: To investigate efficacy of combination of early intelligence intervention with monosialotetrahexosylganglioside(GM1) sodium treatment on rehabilitation outcome of neonatal hypoxic-ischemic encephalopathy(HIE).Methods: Seventy-four cases of neonatal HIE were enrolled and randomly assigned into two groups:the treatment group who received both GM1 sodium and early intelligence intervention(41 cases);control group who received GM1 sodium alone(37 cases).The neonates were assessed by the Gesell Development Scale at age of 6 months.Results: The average scores in the treatment group for functions of gross motor,fine motor,language,and social reactions were all higher than that of the control group(P<0.05 to P<0.01).Conclusions: Early intelligence intervention led to better neurodevelopmental outcome in neonatal HIE by improving cognitive development and perceptual skills.