Effect of the pemetrexed combined with cisplatin in the treatment of advanced lung adenocarcinoma

Objective: To observe the effects and adverse reactions of pemetrexed combined with cisplatin in the treatment of advanced lung adenocarcinoma.Methods: One hundred and thirty-six patients with stage Ⅲ/Ⅳ lung adenocarcinoma were randomly divided into the control group and experimental group(68 cases each group).The control group and experimental group were treated with pemetrexed combined with cisplatin and paclitaxel combined with cisplatin,respectively.The efficacy and adverse reactions in two groups were evaluated.Results: The total effective rate and disease control rate in the experimental group were 50.0% and 97.1%,respectively,which was significantly better than the total efficiency(30.9%) and disease control rate(82.4%) in the control group(P<0.01).The survival rate in experimental group(98.5%) was significantly higher than that in the control group(83.8%)(P<0.01).The incidence rates of leukopenia and thrombocytopenia in the experimental group were significantly lower than those in the control group(P<0.05).Conclusions: The treatment of advanced lung cancer with pemetrexed combined with cisplatin is good effects,little side effects and good tolerance.