The expression of TIP30/CC3 in nasopharyngeal carcinoma tissue and its significance

Objective:To detect the expression of TIP30/CC3 in nasopharyngeal carcinoma tissue,and its role in tumor metastasis.Methods:The expressions of TIP30/CC3 in 30 non-nasopharyngeal carcinoma and 60 nasopharyngeal carcinoma tissue samples were detected by immunohistochemical S-P method,and the relationship between the clinical and pathological parameters was analyzed.Results:The positive expression rate of TIP30/CC3 in non-nasopharyngeal carcinoma tissue(66.7%) was higher than that in nasopharyngeal carcinoma tissue(43.5%)(P<0.01).The differences of the expression rate of TIP30/CC3 in nasopharyngeal carcinoma tissue of patients with different T stage,pathological type,age and gender were not statistically significant(P>0.05).The expression of TIP30/CC3 in nasopharyngeal carcinoma tissue with lymph node metastasis(N2)(31.0%) was lower than that in nasopharyngeal carcinoma tissue without lymph node metastasis(72.2%)(P<0.05).Conclusions:The expressions of TIP30/CC3 in non-nasopharyngeal carcinoma and nasopharyngeal carcinoma tissue are high and low,respectively.The low expression of TIP30/CC3 in nasopharyngeal carcinoma tissue is related to the lymph node metastasis,which suggests that the TIP30/CC3 may be the important index in the occurrence,development,metastasis and prognosis of nasopharyngeal carcinoma.